The aim of this study was to evaluate the association of baPWV as an index of arterial stiffness in the lower-extremity arteries and CAS in patients with type 2 diabetes with atypical chest pain using non-invasive MSCT angiography. However, there is little evidence regarding the relationship between baPWV and the presence of coronary artery stenosis (CAS) as evaluated by MSCT angiography in patients with type 2 diabetes mellitus who have atypical symptoms and equivocal exercise test results. However, in those studies, the participants were relatively healthy, as they drawn from members of the general population who underwent routine health evaluations, and the proportion of patients with diabetes was only 10% to 18%. Recent studies have demonstrated that baPWV was closely associated with risk factors for CVD in patients with occult CAD detected by MSCT. The newest-generation multi-slice computed tomography (MSCT) is considered to be an accurate imaging method for detecting significant CAD however, radiation exposure and its high cost restrict the use of MSCT as a screening tool to detect asymptomatic CAD. The measurement of baPWV has been validated, and the reproducibility of baPWV was also previously reported elsewhere. The baPWV is considered to be a simple tool for assessing vascular damage reflecting stiffness of the aorta and/or the peripheral arteries. Brachial ankle pulse wave velocity (baPWV) measurements have recently become available as a tool for estimating PWV and baPWV can be measured more simply than the carotid-femoral PWV, which is not easy to measure in routine clinical settings. Pulse wave velocity (PWV) is a simple, noninvasive method for estimating arterial stiffness, and it is a predictor of the severity of vascular damage and the prognosis of CVD in patients with hypertension and diabetes. In addition, early detection of patients at a high risk of CVD is critical. Thus, the integrated management of multiple risk factors including hypertension, dyslipidemia, and diabetes is essential for the prevention of future cardiovascular disease (CVD).
The prevalence of asymptomatic CAD and the incidence of sudden cardiac death are much higher in patients with a long duration of diabetes than in those with a short duration. Coronary artery disease (CAD) is major cause of death in individuals with diabetes, and asymptomatic CAD develops more frequently in person with diabetes than in the healthy population.
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